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Drug to Antibody Ratio

Drug to antibody ratio, \(DAR\), is the number of payload molecules conjugated on average to antibody backbone. In the model, it is used to determine how many molecules of payload are released via deconjugation.

Drug to Antibody Ratio in Assess

Drug to antibody ratios are determined experimentally following payload conjugation. The typical range for \(DAR\) is 1-8.

References

  • Fu Z, Li S, Han S, Shi C, Zhang Y. Antibody drug conjugate: the "biological missile" for targeted cancer therapy. Signal Transduct Target Ther. 2022 Mar 22;7(1):93. doi: 10.1038/s41392-022-00947-7. PMID: 35318309; PMCID: PMC8941077.