ADC Deconjugation Half-life

ADC deconjugation half-life, \(t_{1/2, deconj}\), is the half-life of non-specific release of payload from the ADC and free antibody production in the extracellular environment. It describes the time it takes for the fully conjugated ADC to become completely deconjugated.

ADC Deconjugation Half-life in Assess

ADC deconjugation average half-life for complete deconjugation. Combined with a given ADC’s DAR, it determines how much free payload is released over a defined time interval.